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A Nanoliposomal - Amino
Acid Complex as a Potent Growth Hormone Secretagogue; a Second
Look.
Journal of Anti Aging Protocology, Vol. X, XX, March 2008.
Gordon, ML. Gordon, EF, Gordon, AM.
Summary
In
2001, the formulation of Secretropin was completed and a small study
was performed with a report being published. Between 2001 and 2006,
the product was sold quietly to patients that preferred not to
pay the high price of rhGH. We also used it in our
offices as an interval product between cycling on and
off of rhGH.
In
2006, a second more extensive study was begun which incorporated
biochemical testing that was not recognized as being important at
the time of the original study. After a 12
month testing period, the amino acid complex was shown to increase
circulating IGF-1 to a physiological and therefore, therapeutic
level. Laboratory testing was performed prior to starting the
preparation and at 1, 3, and 6 months during continuous product
use. There were no complaints or side-effects encountered
during testing. A subjective inventory was obtained at
each office visit to address the participant’s perceptions of
psychological, physiological and physical
changes.
Secretropin is a growth
hormone secretagogue. Originally developed and tested in 2001,
the product virtually sat on the shelf due to the availability of
recombinant human growth hormone (rhGH). Unfortunately, changes in
the political pharmaceutical industry created both financial and
legal obstacles to the on-going use of rhGH. Therefore, it
became necessary to reassess alternative products which would
increase growth hormone levels in laboratory documented deficient
individuals, and also be cost effective.
In October 2006, an initial study
group of 50 individuals was employed for a prospective,
12-month study on the product's efficacy on
increasing IGF-1 and IGFBP-3 levels. As this study
approached completion in January 2008, a
subsequent study design was begun to include multiple
centers for a continued long term assessment of the product's
efficacy. We anticipate employing hundreds of new patients. It
is the goal of these studies to constantly show the
efficacy and related benefits from a amino acid complex growth
hormone stimulator.
Download the entire
study
Active Ingredients: Pyroglutamine,L-Glutamine,
L-Arginine, L-Lysine, L-Valine,L-Tyrosine Alpha-ketoglutarate,
L-Ornithine, L-alphaglycerlphosphoryl-choline, Gamma Amino Butyric
Acid(GABA), and Mucina pruriens.
Other Ingredients:
Deionized water, Lecithin, Phospholipids, Sodium
citrate, Citric acid, Maltodextrin, Potassium sorbate,
Artificial color and Flavour.
Standard
Serving: Two(2) pumps in the morning and
four(4) pumps at night.
Advanced Serving:
Individuals larger than 250 pounds may need to increase the morning
dose from two(2) pumps to four(4) pumps.
Each Morning, upon
arising, pump 2 sprays under the tongue and hold for 30 seconds
before swallowing. Perform this process 30
minutes before a meal and then wait 30 minutes before eating or
drinking. If you eat, then wait 30 minutes before
using.
Each
Evening, place 4 sprays under the tongue and hold for 30
seconds before swallowing. Perform this process
30 minutes before a meal and then wait 30 minutes before eating or
drinking. If you eat, then wait 30 minutes before
using.
Immediately
upon arising in the morning and just before bed
time!!
This product is not
intended for use by anyone under the age of 18 years. This product
should not be used if you are pregnant or nursing. Keep this product
out of reach of children. Do not use if seal is broken.
In the event of any adverse reaction immediately discontinue use
and consult your
physician.
Laboratory Testing and
Secretropin: Secretropin works
within the body’s regulatory mechanisms to increase the amount of GH
that is produced and released by the anterior pituitary gland (The
Master Gland). In response to an increase in the production and
release of growth hormone the body’s natural tendency is to decrease
the level. Normally, there is an up and down production of growth
hormone throughout the night and early morning. Your doctor will run
blood tests that can still show that there had been an increase in
the production of growth hormone and IGF-1.
Ideally,
serum testing will suffice for monitoring the response
from Secretropin. Salivary
testing serves little or no function relative to any treatment
protocols. To learn about the relationship between Growth Hormone,
Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding
Protein-3; Click
Here
The GH,
IGF-1, and IGFBP-3; The
Relationship
Growth
Hormone: The half-life of human growth hormone in
serum is about 20 minutes making it an unreliable hormone to measure
on a random basis since its measurement represents a snapshot of the
blood.
Urine Growth
Hormone: Either by 24 hour or first morning
urine testing the level of human growth hormone can be
accurately measured. This mode of testing in conjunction with IGF-1
and IGFBP-3 is gaining ground as a reproducable means of diagnosing
Adult Growth Hormone
Deficiency.
Insulin-like Growth
Factor-1: The half-life of IGF-1 has for
many years been accepted as being 20 hours while in
fact, it is only 8 minutes. The extended half-life is based
upon its prolonged survival in the blood when attached to the
carrier protein IGFBP-3. Therefore, like measurement of
GH, IGF-1's short half-life make its random
testing unreliable.
IGF
Binding Protein-3: This protein is
responsible for binding to IGF-1 thereby extending its half-life
from 8 minutes to 20 hours. Free or unbound BP-3 has a
half-life of 20 hours. This makes BP-3 an ideal inferential marker for growth hormone
since (so far) only GH, Estradiol and Quercitin increase the
production of IGFBP-3 from the
liver.
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Less than
500 ug/g
Creatine |
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DHEA-s |
Median for
gender at 25-25 y/o |
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Free
Testosterone |
Median for
gender at 25-25 y/o |
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Dihydrotestosterone |
Median for
gender at 25-25 y/o |
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Estradiol
(E2) |
Median for
gender at 25-25 y/o |
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Pregnenolone |
Median for
gender at 25-25
y/o |
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Less than
500 ug/g
Creatine |
Ideally, all three
of these tests need to be low in order to support a
diagnosis of Adult Growth Hormone Deficiency. Due to
Secretropin's ability to increase GH/IGF-1
and BP-3, we recommend an initial three month trial in any
patient that is non-medically challenged before deciding on
injectable Growth Hormone. As always, the final decision will be
between the physician and the patient.
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