Diagnostic Testing

Health problems and confusing symptoms are not always easy to resolve. The human body usually does not reveal its deficiencies with superficial investigations. Lab tests to pinpoint the contributing causes of symptoms and disease are not commonly performed by conventional doctors.

Dr. Bronner is an expert in functional medical testing. If necessary Dr. Bronner can order any lab or diagnostic test that is currently available. The following are some of the tests available to his patients.

Endocrine Testing

Female Hormone Profile - analyzes eleven saliva samples over a 28-day period for the levels of ß-estradiol, progesterone, and testosterone, providing clues about menstrual irregularities, infertility, endometriosis, breast cancer, and osteoporosis.

Estrogen Metabolism Assessments - evaluate how estrogen is being processed in the body.

Menopause Profile - examines three salivary samples over a 5-day period to determine levels of ß-estradiol, estriol, estrone, progesterone, and testosterone for women who are menopausal.

Male Hormone Profile - analyzes four saliva samples over a 24-hour period for levels of testosterone, free testosterone, melatonin, and the estrogens.

Comprehensive Thyroid Assessment - a comprehensive analysis of thyroid hormone secretion and metabolism, including central thyroid regulation and activity, peripheral thyroid function, and thyroid autoimmunity.

Bone Resorption Assessment - a simple, direct urinary assay of pyridinium crosslinks and deoxypyridinoline, useful in identifying current rate of bone loss, lytic bone disease, and efficacy of bone support therapies.

Glucose/Insulin Tolerance Test - employs a glucose challenge and blood samples over a four-hour period to assess the relationship of insulin and glucose.

Adrenocortex Stress Profile - is a salivary assay of cortisol and DHEA, imbalances of which are associated with ailments ranging from obesity and menstrual disorders to immune deficiency and increased risk of cardiovascular disease.

Comprehensive Melatonin Profile - analyzes three saliva samples for the secretion pattern of this important hormone.

IGF-1 (Insulin-like Growth Factor-1 or Somatomedin C) - mediates many of the in vivo cell division and metabolic effects of growth hormone.

Gastrointestinal Testing

Comprehensive Digestive Stool Analysis - evaluates digestion and absorption, bacterial balance and metabolism, parasite infection, yeast and immune status.

Comprehensive Parasitology Profile - evaluates stool for presence of parasites and levels of beneficial flora, imbalanced flora, pathogenic bacteria, and yeast.

Intestinal Permeability Assessment - analyzes urine for the clearance of two non-metabolized sugars, lactulose and mannitol. Identifies "leaky gut" and malabsorption.

Heliobacter pylori Stool Antigen Test - an FDA-approved evaluation of H. pylori antigens shed directly in the stool. This test is useful for detecting the major causal bacterium associated with peptic ulcers, chronic gastritis, and increased risk of gastric cancer. This noninvasive test also provides a simple and sensitive clinical tool for monitoring eradication therapy.

Total Element Clearance Profile (24 hr and Random/Timed) - measures urinary excretion of 9 nutrient elements and 20 toxic metals, including "classic" toxics such as lead, mercury, and arsenic, as well as newer technology toxics such as niobium and gadolinium.

Metabolic Testing
Cellular Energy Profile - evaluates fourteen organic acids that play a pivotal role in the generation of cell energy. Using a urine sample, the test can reveal metabolic distress associated with generalized pain and fatigue, which may arise in response to toxic exposure, nutrient imbalances, digestive dysfunction, and other causes.

Comprehensive Detoxification Profile - analyzes saliva, blood, and after- challenge doses of caffeine, aspirin, and acetaminophen in order to assess the Phase I and Phase II functional capacity of the liver to convert and clear toxic substances from the body. This profile includes markers for oxidative stress and important antioxidants.

Oxidative Stress Analysis - identifies markers of hydroxyl radical activity, urine lipid peroxides, reduced glutathione, superoxide dismutase, and glutathione peroxidase, following a challenge dose of aspirin and acetaminophen.

Comprehensive Cardiovascular Profile - analyzes blood for levels of HDL, LDL, lipid fractionation, total cholesterol, ratios, triglycerides, lipoprotein(a), homocysteine, fibrinogen, and high-sensitivity C-reactive protein. Includes Relative Risk Indices and Metabolic Syndrome Alerts.

SpectraCell FIA 5000 - measures how micronutrients are actually functioning within your patients’ white blood cells. These tests allow nutritional assessment of your patients for a broad variety of clinical conditions including arthritis, cancer, cardiovascular risk, diabetes, various immunological disorders, metabolism disorders and micronutrient deficiencies.

Genetic Base Testing

Our predictive genomic profiles assess genetic variations in each person that, when combined with modifiable factors in the environment, may increase disease risk. This empowers physicians and patients to realize earlier, more effective preventive interventions-years before disease develops. It also enables precise, customized therapies that truly address each individual's need, and improved clinical insight into patients with treatment-resistant "chronic" conditions.

CardioGenomic™Profile - identifies genetic single nucleotide polymorphisms associated with increased risk of developing atherosclerosis, hypertension, and coronary artery disease. Risk factors include methylation defects, hyper-coagulation syndromes, cholesterol regulation defects, inflammation, general risk markers and cardio-protective markers.

OsteoGenomic™Profile - identifies genetic single nucleotide polymorphisms associated with increased risk of developing osteopenia and osteoporosis. Risk factors include collagen synthesis, calcium metabolism, vitamin D3 activity, parathyroid hormone action, osteoclastic activity, and chronic inflammation.

DetoxiGenomic™Profile - identifies genetic single nucleotide polymorphisms associated with increased risk of developing detoxification defects especially with increased exposure to xenobiotics and other toxins. Risk factors include altered cytochrome P-450 activity in phase 1 detoxification, impaired glutathione conjugation and acetylation in phase 2 reactions, altered catecholamine methylation and increased oxidative stress. Detoxification defects have been associated with increased risk for certain cancers, chronic fatigue, multiple chemical sensitivity, and alcoholism.

ImmunoGenomic™Profile - identifies genetic single nucleotide polymorphisms associated with increased risk of developing defects in immune competence and surveillance. Risk factors include altered interleukin production and activity within the body and increased production of other cytokines like tissue necrosis factor alpha that may lead to conditions characterized by chronically up-regulated inflammatory response. Immunologic polymorphisms have been associated with increased risk of asthma, atopy, osteopenia, heart disease, and infectious diseases.
Imaging Scans

Dr. Bronner can provide access to all diagnostic imaging services such as radiology, CAT, PET, MRI and Ultrasound.

Bioelectrical Impedance Analysis - considered one of the most exact and accessible methods of screening body fat. In conventional BIA, a person is weighed, then height, age and gender are entered in a computer. While the person is lying down, electrodes are attached to various parts of the body and a small electric signal is discharged that measures the impedance or resistance to muscle and fat. The more muscle, the lower the value, as the electricity passes easily through lean mass. A formula in the computer converts all of the data to indicate what percentage of the body is fat.

Carotid Intima Media (CIMT) Testing - uses ultrasound to identify the early and intermediate stages of atherosclerosis, even if you show no outward signs or symptoms of the disease. Also measures the degree of inflammation in the arterial wall or the size of the plaque that may contribute to heart disease.

Diagnostic Testing

Distinguishing ADHD, The Diagnostic and Statistical Manual of Mental Disorders IV, Published by the American Psychiatric Association, describes three subtypes of ADHD:

  • Inattentive - has trouble getting focused or maintaining focus on a task or activity
  • Hyperactive Impulsive - very active and acts without thinking
  • Combined - inattentive, impulsive and hyperactive

Facts About ADHD

  • Three times as many boys as girls suffer from ADHD.*
  • 78% of pediatric prescriptions are for attention issues.*
  • Half of the children with ADHD also have a learning disability.*
  • 50-80% of ADHD cases diagnosed in childhood persist into adolescence.*
  • 30-50% of adolescent cases of ADHD persist into adulthood.*

* Data adapted from the St. Louis Psychologists and Counseling Information and Referral.

If left untreated, children with ADHD can develop self-destructive behaviors. They can fall behind in academics and are more likely to drop out of school. These children are more prone to altercations with authority figures and law enforcement officials, and to experiment with drugs and alcohol. They also are more likely to become injured in accidents due to risk-taking.

ADHD & Neurotransmitter Levels

ADHD is among the most common neurotransmitter-related conditions. Others include anxiety disorders, compulsive behaviors, insomnia, depression and migraines.

Neurotransmitters are chemicals that relay signals between nerve cells, called “neurons.” These are present throughout the body and are required for proper brain and body functions. Serious health problems can occur if neurotransmitter levels are too high or too low. Every neurotransmitter behaves differently. Some neurotransmitters are inhibitory and tend to calm the brain. Others are exciting and have the opposite effect. Scientific research reveals a close link between mental acuity (the ability to focus) and appropriate levels of various neurotransmitters in the central nervous system, including dopamine, serotonin, GABA, glycine, norepinephrine, and glutamate.

Research also links three major neurotransmitters—serotonin, GABA, and glycine—with calming and impulse control. Environmental and biological factors—including stress, poor diet, neurotoxins, or genetics—can cause imbalances in the levels of neurotransmitter chemicals in the brain. Imbalances can trigger or exacerbate ADHD symptoms.

Improving Treatment

Most of the drug-based methods used to treat behavioral issues include chemicals that either imitate a neurotransmitter or redistribute existing neurotransmitters. Many affect norepinephrine, and some affect other neurotransmitters like GABA, serotonin, or dopamine.

It is generally believed that drugs supporting norepinephrine signaling will be beneficial when behavioral issues result from a lack of norepinephrine and that GABA supporting drugs will be effective when a person’s symptoms are caused by a lack of GABA.

While the idea of matching a drug to a chemical imbalance is generally supported, the vast majority of healthcare providers prescribe psychological drugs based on a patient’s symptoms, and few try to match a drug to a biochemical imbalance. This may explain why some drugs are ineffective for some patients.

Neurotransmitter function can also be supported with nutrient-based programs. Neurotransmitters are made from various components of food in a normal, healthy diet. Increasing the amounts of these dietary constituents can help maintain normal neurotransmitter levels.

While no program can guarantee success for everyone, it is worthwhile to effectively match a drug-based and/or nutrient-based program to the specific needs of the individual. Read more about TAAT here

Contact Dr. Bronner about Natural ADD/ADHD Treatments